This unique pathological condition is characterized by the growth of a skeletal spike that, in extreme cases, perforates the soft tissue envelope. The ability of bone to regenerate after congenital transdiaphyseal amputation has been recognized since the 1940s and includes numerous case reports of digital phalanx regeneration and a more striking skeletal condition unique to children, known as Juvenile Amputee Overgrowth (JAO). Apart from fracture healing which is most commonly observed, bone regeneration has also been observed in humans after amputations, especially in children. Similarly, the skeleton is likely to be fractured which necessitates the ability of fractured bone to regenerate and undergo repair. Specifically, the liver is the main detoxifying organ of the body and is likely to be injured by ingested toxins. These unusual regenerative properties of certain tissues are a logical adaptation of organisms that are likely to be injured. In mammals, deer can regenerate their antlers and mouse their ears. Indeed epimorphic regeneration occurs in certain animals, such as salamanders and frogs, which are able to regenerate limbs, tails, jaws, eye lenses. Although, Prometheus is a mythical creature, liver regeneration in humans is a scientific fact. In the Greek myth, an eagle fed from his liver each day, but the liver regenerated overnight.
Tissue regeneration is a biological process appreciated since the Bronze Age, from the ancient Greek myth of Prometheus and his punishment for deceiving the gods and protecting mankind.
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